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  • Interview by Anna Stevens
Sophie Wright

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SWWe’re always busy at Magnum! Currently we’re working on our next Print Room exhibition called Political Landscapes, an exploration of the rise of issue-based landscape as a genre within the membership. I’m also negotiating an exhibition of historical material for Qatar next year, as well as investigating other potential collaborations in Saudi and Dubai. There are also 2 big books currently in the pipeline, one on contact sheets with Thames & Hudson, and a collaboration with WWF, both due for publication in 2011. My colleagues in Cultural are also currently organising a Magnum workshop in Barcelona and we’ve also got various individual photographer projects in development – so it’s hectic to say the least.

In terms of my freelance work, I’m currently concentrating on getting my own website up and running, and have a couple of interesting collaborations up my sleeve.

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SWWhen you talk about “projects” at Magnum it’s probably best to think about the photographers personal work as that is probably of most interest for photographers starting out on something. Magnum’s offices represent the photographers in lots of ways – commercial, editorial, stock sales as well as the areas that I oversee in the cultural department: through exhibitions, books and print sales. The photographers get commissions from clients across all these areas of activity, and sometimes work that was once commissioned becomes something larger for a photographer that they choose to focus on for a longer period of time themselves. The structure of Magnum is also set up so that any reselling of archival material or stock, as it’s known now, is supposed to feed into funds for photographers to pursue their independent projects. As Magnum is set up on a business model, we don’t get public sector funding, so if a photographer has a specific project they need assistance with they and Magnum look for sponsorship or funding from interested parties, be they commercial  or charitable bodies. Finally, print sales is obviously an important source of revenue for many of our members.

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SWPrint sales at Magnum has been a big growth area over the past few years. Magnum London opened our Print Room in 2005 and have also collaborated very successfully with the Atlas gallery since then on UK sales. In addition, we have various partner galleries overseas that we consign material to. There are also successful print sales businesses running out of our New York and Paris offices. 

Magnum’s newer members are increasingly coming to the agency with pre-existing gallery relationships, this is both a reflection of Magnum’s broadening representation of documentary work, and the shift in the markets for this kind of photography. Magnum will always have enthusiasts for it’s work who come to us not because they are collectors but because of their love of the images and that hasn’t changed. It’s the bigger collectors who are now taking more time to consider their next purchase. Sales have obviously slowed down a bit since the recession hit last Autumn, with the recent auctions during Frieze still tentative, but I’m confident they will pick up again.

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SWIt’s hard to choose retrospectively, although in terms of first’s at Magnum I guess working on the first Henri Cartier-Bresson exhibition in the Middle East, which we held at the Emirates Palace in Abu Dhabi earlier in the year was pretty interesting. I’m actually really excited at the potential for the Magnum Contacts project, which we originated through London, and on a smaller scale, I’ve got a lot of fun out of curating our print room exhibitions – shows like New Blood, Documenting Style or our new Political Landscapes show we’ve got coming up.

In terms of my freelance work, I get a lot of pleasure from writing and enjoyed reviewing Jim Goldberg’s new project Open See for Foam magazine earlier in the year.

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SWI will always remember being told by the then Chairman at Tate, who a contact of mine had very kindly set me up to meet when I was young and relatively green, that “getting a job in the art world is like hitting your head against a brick wall until a brick falls off”. Clearly I must have been a masochist because there was no specific break as such, just as with everything else, a determination not to give up until I got somewhere. You should also never underestimate the benefit of mentors – I’ve had some good advice from people I admire over the years. It’s important to have people further down their careers that you can both talk to and aspire to be like as it’s a long game in this industry and one based on tenacity and a good network of supporters and clients.

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SWPhotography is an individualistic occupation however, it’s a fallacy to think that you’ll get anywhere without the help or collaboration of others. Writers and curators make up some of those advocates. 

It’s a very exciting time in London at the moment, as we’ve got Charlotte Cotton back in the UK from LACMA heading up the satellite space of the National Media Museum in London, in addition to a very nice chap called Simon Baker, who is the first photography curator hired by the Tate, so it feels like the possibilities for photography in London are developing. I’m a big fan of the work that David Chandler does at Photoworks in Brighton, and further afield we’re currently working with Kristen Lubben at ICP on the Magnum Contacts book, who produced a really great exhibition and book “In History” on Susan Meiselas’s work last year. In terms of writers David Campany and Geoff Dyer are also worth checking out.

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Sophie Wright is an advisor to Contact Editions. She is the Cultural and Print Room Director at London and a freelance Creative Consultant and has over 10 years experience in the photographic industry.  Here Sophie discusses her role at Magnum, her views on the current photographic market and shares advice with those starting out in the photographic industry.

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Contact is taking submissions for our new festival of photography and multimedia, Night Contact. We are looking for interesting and innovative bodies of work to be projected as part of the festival, which will take place in London on the 27th September 2013.

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MDSC suppressive activity was determined by admixing MDSCs with CFSE-labeled HA-specific CD8+ (clone 4) or CD4+ (6.5) T cells pulsed with their relevant peptide in the presence or absence of sildenafil (Fig. 7, A and B). Although the addition of tumor-derived MDSCs significantly impaired antigen-specific T cell proliferation as demonstrated by the low percentage of CFSElow clonotypic T cells, sildenafil almost completely restored both CD4+ and CD8+ responsiveness of these antigen-specific T cells. The absence of sildenafil-mediated enhancement in T cell function in the groups lacking CD11b+ cells underscores the targeted role of sildenafil on the MDSC population. Because in a Th1 cellprone environment MDSC suppression is only NOS2 dependent (34), we examined the role of PDE5 in MDSCs in a C57BL/6 background where NOS2/ mice are also available. CD11b+ MDSCs were isolated from either C57BL/6-NOS2+/+ or B16GM-bearing C57BL/6-NOS2/ B16GM melanoma-bearing mice. A suppression assay was performed by stimulating OVA-specific CD4+ T cells with the relevant peptide in the presence or absence of MDSCs obtained from either NOS2+/+ or NOS2/ tumor-bearing mice (Fig. 7 C). Although the addition of C57BL/6-NOS2+/+ MDSCs induced considerable T cell suppression, no suppression was observed with MDSCs from NOS2/ mice. Furthermore, although PDE5 inhibition reversed MDSC suppression in NOS2+/+ mice, sildenafil failed to augment T cell responsiveness in the NOS2/-derived MDSC suppression assay. These results confirm the role of NOS2 in MDSC-mediated T cell suppression (Fig. 7 C) and underscore the ability of PDE5 inhibition to reverse the two major suppressive pathways in MDSCs (ARG1 and NOS2). cialis for sales Low levels of testosterone rarely lead to erection problems, but may reduce a man's sex drive. 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In these hosts, sildenafil demonstrated no antitumor efficacy. Because these mice lack T and B lymphocytes but have normal or enhanced NK and NKT activity (17, 18), these results strongly suggest that the antitumor activity of PDE5 inhibition in our models is primarily caused by an adaptive immune response with either minimal NK/NKT-mediated activity, direct tumor-induced apoptosis, or tumor angiogenesis inhibition. Although the hallmark feature of MDSCs is immunosuppression, emerging data reveal that the degree of immunosuppression varies among populations of MDSCs isolated from different organs, with intratumoral MDSCs being the most immunosuppressive. Interestingly, these MDSCs express greater levels of NOS2 and ARG1 than their splenic counterparts (5). ARG1 expression is mainly regulated by the STAT-6IL-4R pathway (30). We recently correlated IL-4R expression on CD11b+/Gr-1+ with an immunosuppressive phenotype (29), and our in vitro data (Fig. 5) indicate that sildenafil down-regulates IL-4R on MDSCs. We then asked whether in vivo PDE5 inhibition reduced ARG1 and NOS2 and down-regulated IL-4R in tumor-associated MDSCs. BALB/c mice were challenged with CT26WT, and half were treated with sildenafil. Mice were killed 15 d later, and intratumoral MDSCs were obtained. Sildenafil increased cGMP (Fig. 6 A), reduced IL-4R expression (Fig. 6 B), and down-regulated NOS2 and ARG1 expression and reduced their enzymatic activity in the intratumoral MDSCs (Fig. 6, C and D). Considering that ARG1 and NOS2 are key enzymes in MDSC suppressive pathways (8, 31), these findings support the hypothesis that PDE5 inhibition is a novel pharmacologic approach to regulate MDSC-mediated immunosuppressive pathways. The latest Erectile Dysfunction News & Premature Ejaculation News articles published daily. 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