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Due to its embarrassing nature and the shame felt by sufferers, the subject was taboo for a long time, and is the subject of many urban legends. Folk remedies have long been advocated, with some being advertised widely since the 1930s. The introduction of perhaps the first pharmacologically effective remedy for impotence, sildenafil (trade name Viagra), in the 1990s caused a wave of public attention, propelled in part by the news-worthiness of stories about it and heavy advertising.
the blood brim is decreased and erection goes away.
Penile erection is mainly mediated by the parasympathetic nervous system, which when stimulated causes arterial dilation and relaxation of the cavernosal smooth muscle. The increased blood flow into the corpora cavernosa in association with reduced venous outflow results in penile rigidity.
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PDE-5 inhibition increases cGMP activity, which increases vasodilatory effects of NO. Sexual stimulation is necessary to activate response. Because sexual stimulation is required to initiate local release of NO, tadalafil has no effect in absence of sexual stimulation. Increased sensitivity for erections may last 36 h with intermittent dosing. Low-dose daily dosing may be recommended for more frequent sexual activity (ie, twice weekly); men can attempt sexual activity at anytime between daily doses. Available as 2.5-, 5-, 10-, and 20-mg tabs.
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Lifestyle choices that contribute to heart disease and vascular problems also raise the risk of erectile dysfunction. Smoking, being overweight, and avoiding exercise are possible causes of ED.
What sexual techniques do you use?
FRIDAY, Sept. 25 (HealthDay News) -- Scientists may have discovered a novel way to treat erectile dysfunction -- using the venom of a deadly spider.
Identical to naturally occurring PGE1 and has various pharmacologic effects, including vasodilation and inhibition of platelet aggregation. When injected into the penile shaft, it relaxes trabecular smooth muscle, dilating cavernosal arteries, which, in, turn promotes blood flow and entrapment in the lacunar spaces of the penis, causing penile erection. Various doses have been used.
Hemoglobin A1c, serum chemistry studies, lipid profiles, and prostate-specific antigen levels should be obtained unless the patient has recently had these studies performed and the results are available.
Then, the study participants were given 50 milligrams of oral sildenafil; 45 minutes later, resting and post-exercise blood pressure readings were taken again.
In their experiments, the researchers used mice bred to mimic Duchenne muscular dystrophy. Then the scientists gave the rodents doses of Viagra comparable to those taken by men for erectile dysfunction.
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ViagraŽ is absorbed and processed rapidly by the body and is usually taken 30 minutes to 1 hour before intercourse. Results vary depending on the cause of erectile dysfunction, but studies have shown that Viagra is effective in 75% of cases. It helps men with erectile dysfunction associated with diabetes mellitus (57%), spinal cord injuries (83%), and radical prostatectomy (43%).
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